Genome Study Shifts Cancer Categories from Tissues to Molecular Subtypes
After analyzing molecular and genetic characteristics of more than 3,500 tumor samples of 12 cancers, the US scientists at the University of California, Santa Cruz, have discovered new evidence. This is the largest cancer
genomic study ever. It's led by U. S. National Cancer Institute and U. S. National Human Genome Research Institute.
The study participants included researchers from the University of California, Santa Cruz, and Buck Institute for Age Research, University of North Carolina Health Care and University of California, San Francisco.
The results from the evidence suggest that cancers from a particular tissue may comprise cancers of different subtypes, each with a different prognosis, each vulnerable, possibly, to different therapies. A new classification system for cancer could also affect drug development or the recruitment of patients into clinical trials.
At least three different subtypes of bladder and breast cancers were identified. Bladder subtypes includes a cancer that is identical to non-small cell lung cancer known as adenocarcinoma. Other similar squamous-cell cancers were found in the head and neck.
According to recent findings published in the journal Cell, the new cancer classification system will now show the molecular subtypes of the tissue's origin and can possibly lead to improved therapeutic options for patients.
Dr. Christopher Benz, a cancer specialist in breast cancer treatment, says, "The findings may help explain why patients with bladder cancer often respond very differently when treated with the same systemic therapy".
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